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Table 4 Estimated parameters with CV 0.3 or less

From: Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

ID: Parameters

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Patient 6

Patient 7

71: CLr (CPT-11)

0.10

0.07

0.12

0.11

0.18

0.25

0.18

72: CLr (SN-38)

–

–

–

0.28

–

–

–

76: CLbile (CPT-11)

0.10

0.10

0.18

0.10

0.13

0.30

0.20

80: CLbile (APC)

–

–

0.26

0.27

–

–

–

82: CLCES,2

–

–

–

–

0.27

–

–

83: CL3A4,1

0.12

0.08

0.12

0.08

0.23

0.28

0.18

  1. CV coefficient of variation, Bars represent CV is 0.3 over