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Table 3 Top 20 predicted disease genes for obesity, prostate cancer and lung cancer

From: Gene gravity-like algorithm for disease gene prediction based on phenotype-specific network

Obesity Prostate cancer Lung cancer
rank Gene symbol Class rank Gene symbol Class rank Gene symbol Class
1 ADRB2 1 AR 1 EGFR
2 PPARG 2 PTEN 2 ERBB2
3 ADRB3 3 ZFHX3 3 BRAF
4 MC4R 4 BRCA2 4 KRAS
5 ENPP1 5 CDH1 5 CASP8
6 GHRL 6 CHEK2 6 PIK3CA
7 UCP3 7 HIP1 7 PARK2
8 NR0B2 8 MXI1 8 FASLG
9 POMC 9 MAD1L1 9 MAP3K8
10 CARTPT 10 KLF6 10 RASSF1
11 UCP1 11 MSR1 11 IRF1
12 PPARGC1B 12 CD82 12 ERCC6
13 AGRP 13 TP53 * 13 SLC22A18
14 SDC3 14 BRCA1 * 14 PPP2R1B
15 HNF4A ~ 15 MAD2L1 ~ 15 DLEC1
16 ESR1 * 16 EGFR * 16 HRAS *
17 SIM1 17 SIN3A * 17 AKT1 *
18 MC3R * 18 MAX * 18 TP53 *
19 MC1R * 19 CTNNB1 ~ 19 GRB2 ~
20 LEP * 20 MYC * 20 TGFBR2 *
  1. Genes with class mark √ is known disease genes in the OMIM database; * denotes the predicted disease genes with literature or database support; ~ is the predicted genes without evidence
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