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Fig. 3 | BMC Systems Biology

Fig. 3

From: Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology

Fig. 3

Prediction of estradiol kinetics in women. Estradiol venous blood concentrations were simulated for the 1495-person virtual population following a 0.3 mg i.v. bolus and b 2 mg or 4 mg oral bolus exposures, and presented as mean (±s.d.). The i.v. bolus data was compared to clinical data from Kuhnz et al. [45], which is shown as mean (±s.d.), while oral dose simulations were compared to clinical data from Lyrenas et al. [47]

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