Prediction of estradiol kinetics in women. Estradiol venous blood concentrations were simulated for the 1495-person virtual population following a 0.3 mg i.v. bolus and b 2 mg or 4 mg oral bolus exposures, and presented as mean (±s.d.). The i.v. bolus data was compared to clinical data from Kuhnz et al. , which is shown as mean (±s.d.), while oral dose simulations were compared to clinical data from Lyrenas et al.