Parameters | Value | Biological significance |
---|---|---|
V | 1 ml | Total volume |
uMmM | 1000 | Converts μM to mM |
τ min | 60 | Converts minutes to seconds |
p cytosol | 0.5 | Proportion of volume occupied my cytosol |
d cytosol | 75 mg/ml | Density of cytosolic protein mg/ml |
p mito | 0.05 | Proportion of volume occupied my mitochondria |
d mito | 1000 mg/ml | Density of mitochondrial protein mg/ml |
p er | 0.1 | Proportion of volume occupied my ER |
d er | 1000 mg/ml | Density of ER protein mg/ml |
c mito | 0.0725 \(\frac {nmol}{mV*mg}\) | Mitochondrial calcium concentration |
ρ uni | 300 \(\frac {nmol}{mg*min}\) | Maximum rate of transport through mitochondrial uniporter |
\(\rho _{Na}^{Ca} \) | 3 \(\frac {nmol}{mg*min}\) | Maximum rate of transport through Na+/Ca2+ exchanger |
ρ res | 0.4 | Mitochondrial respiration co-efficient |
ρ F 1 | 0.7 \(\frac {nmol}{mg*min} \) | Mitochondria - Fo/F1 ATPase |
[P i ] m | 20 mM | Concentration of free phosphates |
ρ leak | 0.2 \(\frac {nmol}{mg*min} \) | Mitochondrial membrane proton leak |
J red,basal | 20 \(\frac {nmol}{mg*min}\) | NADH reduction rate |
J max,ANT | 900 \(\frac {nmol}{mg*min}\) | ATP/ADP antiport flux |
glc | 1 mM | Glucose concentration in cytosol |
J hyd,max | 30.1 mM | Cytosol hydrolysis of ATP |
V IP3 | 3000 μM | IP3 receptor volume |
V leak | 0.1 | proportion of leakage from IP3 receptor |
J leak | 0.1 | ER leak |
d IP3 | 0.25 μM | IP3 receptor sensitivity |
d ACT | 1 μM | IP3 receptor Ca2+ activation constant |
d INH | 1.4 μM | IP3 receptor Ca2+ inhibition constant |
τ | 4 s | IP3 receptor inhibitory time constant |
V serca | 110 \(\frac {nmol}{mg*min}\) | SERCA pump flux |
k serca | 0.4 μM | SERCA pump Ca2+ sensitivity |
V 1 | 0.0065 nM/s | Constant rate of β-amyloid synthesis |
V α | 0.05 nM/s | Maximal rate of β-amyloid synthesis |
K α | 120 nM | Half-saturation constant |
k β | 0.2 nM3/s | Rate constant of increased Ca2+ entry |
K 1 | 0.01 s−1 | Rate constant of β-amyloid elimination |
n | 2 | Hill coefficient for activation of β-amyloid synthesis |
m | 4 | Cooperativity coefficient |
f m | 0.0003 | Mitochondrial Ca2+ buffering coefficient |
f i | 0.01 | Cytosolic Ca2+ buffering coefficient |