Table 4 List of model ODEs from [7–9]

dNADH _m /dt=(J _red −J _o )∗M/(uMmM∗V _m ∗minute)

ODE for mitochondrial NADH concentration change (mM/s)

dADP _m /dt=(J _ANT −J_p,TCA−J_p,F1)∗M/(uMmM∗V _m ∗minute)

ODE for mitochondrial ADP concentration change (mM/s)

dADP _i /dt=(−J _ANT ∗M+(J _hyd −J_p,gly)∗C)/(uMmM∗V _c ∗minute)

ODE for cytosolic ADP concentration change (mM/s)

\(dPSI/dt= -\left (-J^{H}_{res} + J_{H,F1} + J_{ANT} +J^{H}_{PTP} +J^{H}_{L} +2*J_{uni} +2 * J^{Ca}_{PTP}\right) * M/\left (c_{mito} * minute \right)\)

ODE for mitochondrial inner membrane voltage

dh/dt=(d _INH −(CAC+d _INH )∗h)/τ

ODE for change in percentage of closed channels