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Fig. 4 | BMC Systems Biology

Fig. 4

From: Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis

Fig. 4

DUSP2 model. (Left). Network map of DUSP2 regulation (cluster 1) in MDA-MB-453 HER2-positive breast cancer cells exposed to Herceptin. (Right). Corresponding Boolean time series represented as a heatmap showing gene expression. Green and red indicate nodes in the ON and OFF states, respectively. Note that time units in Boolean simulations are arbitrary and do not necessarily match the 24 h period of the study, but the overall expression pattern can be compared to the overall Boolean time series

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BMC Systems Biology

ISSN: 1752-0509

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