Annotating activation/inhibition relationships to protein-protein interactions using gene ontology relations

BMC Systems Biology

Table 4 Statistics of PPI datasets that were used for comparison with previous GO-based method

		Activation	Inhibition	Activation&inhibition	Affect	Total
KEGG	Previous work	14,054	5478	382	552	20,466
KEGG	Our work	12,309	4787	369	517	17,982
STRING	Previous work	2849	465	152	15	3481
STRING	Our work	2729	455	152	15	3351

The previous GO-based method covers all PPIs whose constituent proteins are annotated to at least one GO term. However, our method requires at least one positive/negative regulation pair to predict effect type, thereby decreasing our coverage

ISSN: 1752-0509