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Fig. 1 | BMC Systems Biology

Fig. 1

From: In silico drug combination discovery for personalized cancer therapy

Fig. 1

a Reformatted experimental data from O‘Neil’s dataset for analyzing by Combenefit. b Synergy scores calculated by Combenefit. c For predicting synergy scores, each sample is vectorized. The vector contains drug targets, genomic information of a cell line, pharmacological data, and other external knowledge such as synthetic lethality. d and e Predicted synergy scores calculated using various machine learning models. Pearson correlation coefficient and F1 score were used as the evaluation metrics for the regression models and classification models, respectively

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