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Table 4 Synergistic rules

From: In silico drug combination discovery for personalized cancer therapy

Rule Positive Negative p-value Reference
  synergy score synergy score   
Target: mTOR, DNA GEX: underexpressed HES5 23.055 8.651 1.3e−10 [24, 25]
Target: EGFR, mTOR, PI3K GEX: underexpressed SNW1 22.219 8.588 6e−5  
Target: mTOR, PI3K, DNA GEX: underexpressed MAPK14, underexpressed NOTCH4 19.8 6.231 5e−7  
Target: SRC, TOP1 GEX: underexpressed TGFBR2, underexpressed ERBB3 28.089 7.113 2e−5