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Fig. 3 | BMC Systems Biology

Fig. 3

From: Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissue

Fig. 3

Proliferation drives melanoma nest formation. a MTT assays show all metabolically active cells (light purple) on the surface of the 3D experimental skin model initialised with different numbers of proliferating melanoma cells, as indicated. b Equivalent results with irradiated melanoma cells. Melanoma nests are in dark purple (arrows). Scale bars are 1 mm. c-d Box plots showing nest area as a function of initial number of melanoma cells. Outliers are indicated by red crosses. Inset in (d) shows details in the range 0–0.04 mm2

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