Fig. 7From: Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissueMathematical model confirms trends in nest formation data and predicts new results. Box plots of nest size, assuming the area of each melanoma agent is 20 × 20 = 400 μm2, for a typical realisation of the IBM for (a) proliferative melanoma agents; (b) non-proliferative melanoma agents; (c) proliferative melanoma agents where the proliferation rate is reduced by 50%; and, (d) proliferative melanoma agents where adhesion strength is reduced by 50%. In each case, outliers are indicated by red crosses. Results in (a-b) confirm the trends in Figs. 3c-d and 6e-f. Note the difference in the vertical scale in (c-d) compared to (a-b)Back to article page