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Table 4 Significant GO Biological terms and pathway analysis for top 10 hub genes identified from the whole PPI network of DEGs based degree of node

From: Identification of novel drug targets for diamond-blackfan anemia based on RPS19 gene mutation using protein-protein interaction network

Gene Degree GO Term
AKT1 171 cellular response to lipopolysaccharide,
response to cytokine, inflammatory response,
negative regulation of transcription from RNA polymerase II promoter,
immune response
IL6 101 cellular response to tumor necrosis factor,
positive regulation of smooth muscle cell proliferation,
negative regulation of cell proliferation
NFKB1 101 positive regulation of macromolecule biosynthetic process,
cellular response to tumor necrosis factor, immune response
STAT3 99 positive regulation of cell proliferation,
response to cytokine, inflammatory response
STAT1 91 cellular response to tumor necrosis factor,
cellular response to lipopolysaccharide,
response to cytokine, immune response
RAC1 88 immune response
EGR1 79 cellular response to hypoxia
IL8 77 cellular response to lipopolysaccharide, response to cytokine,
inflammatory response, immune response,
regulation of cell communication
RELA 76 positive regulation of cell proliferation,
response to cytokine, inflammatory response
RAC3 75 positive regulation of cell proliferation
mTOR 75 positive regulation of macromolecule biosynthetic process, inflammatory response, immune response