Table 4 Significant GO Biological terms and pathway analysis for top 10 hub genes identified from the whole PPI network of DEGs based degree of node
Gene | Degree | GO Term |
|---|---|---|
AKT1 | 171 | cellular response to lipopolysaccharide, response to cytokine, inflammatory response, negative regulation of transcription from RNA polymerase II promoter, immune response |
IL6 | 101 | cellular response to tumor necrosis factor, positive regulation of smooth muscle cell proliferation, negative regulation of cell proliferation |
NFKB1 | 101 | positive regulation of macromolecule biosynthetic process, cellular response to tumor necrosis factor, immune response |
STAT3 | 99 | positive regulation of cell proliferation, response to cytokine, inflammatory response |
STAT1 | 91 | cellular response to tumor necrosis factor, cellular response to lipopolysaccharide, response to cytokine, immune response |
RAC1 | 88 | immune response |
EGR1 | 79 | cellular response to hypoxia |
IL8 | 77 | cellular response to lipopolysaccharide, response to cytokine, inflammatory response, immune response, regulation of cell communication |
RELA | 76 | positive regulation of cell proliferation, response to cytokine, inflammatory response |
RAC3 | 75 | positive regulation of cell proliferation |
mTOR | 75 | positive regulation of macromolecule biosynthetic process, inflammatory response, immune response |