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Table 8 Verification of the model based on results from published studies

From: The innate immune response to ischemic injury: a multiscale modeling perspective

 

DAMPs

M1

M2

ROS

CCL2

TRIF

CD13

IRF3

INFb

MyD88

pIRAK

NF- kB

Intracellular steady state (from Table 4)

Tissue steady state (from Table 7)

***% injury resolved or unresolved

references

WT

2

1

1

0

1

1

1

1

1

1

1

1

6

1

100%–0%

[49]

MyD88 KO

1

ND

ND

0

0

ND

1

ND

ND

 

0

0

3 or 4

1 or 3*

66%–33%

[72, 73]

IRAK KO

1

ND

ND

0

0

1

1

ND

ND

1

–

0

3 or 4

1 or 3*

66%–33%

[74,75,76]

CCL2 KO

1

ND

ND

0

–

1

1

ND

ND

1

1

1

3 or 4

1 or 3*

66%–33%

[54, 55]

TRIF KO

1

ND

ND

0

1

–

1

0

0

1

1

1

6

1**

100%–0%

[51, 73]

CD13 KO

2

1

1

1

1

2

 

2

2

1

1

1

6

1

100%–0%

[49]

  1. ND values not empirically determined in published studies
  2. * Values not empirically determined for Ml and M2: When we set (M1, M2) = (0, 0) and (2, 0), injury is not resolved as the states result in tissue steady state 3 (Table 7) where DAMPs is at MEDIUM (33%). For the other four possible values of Ml and M2, the states result in tissue steady state 1 from Table 7 where injury is resolved (DAMPs is LOW, 66%)
  3. ** Values not determined for M1 and M2: Assigning all possible combinations (100%) of the missing values result in the largest steady state (steady state 1) where injury is resolved
  4. *** indication of % injury resolved or unresolved resulting from assigning all possible values for undetermined nodes as explained in * and **
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BMC Systems Biology

ISSN: 1752-0509

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