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Table 8 Verification of the model based on results from published studies

From: The innate immune response to ischemic injury: a multiscale modeling perspective

  DAMPs M1 M2 ROS CCL2 TRIF CD13 IRF3 INFb MyD88 pIRAK NF- kB Intracellular steady state (from Table 4) Tissue steady state (from Table 7) ***% injury resolved or unresolved references
WT 2 1 1 0 1 1 1 1 1 1 1 1 6 1 100%–0% [49]
MyD88 KO 1 ND ND 0 0 ND 1 ND ND   0 0 3 or 4 1 or 3* 66%–33% [72, 73]
IRAK KO 1 ND ND 0 0 1 1 ND ND 1 0 3 or 4 1 or 3* 66%–33% [74,75,76]
CCL2 KO 1 ND ND 0 1 1 ND ND 1 1 1 3 or 4 1 or 3* 66%–33% [54, 55]
TRIF KO 1 ND ND 0 1 1 0 0 1 1 1 6 1** 100%–0% [51, 73]
CD13 KO 2 1 1 1 1 2   2 2 1 1 1 6 1 100%–0% [49]
  1. ND values not empirically determined in published studies
  2. * Values not empirically determined for Ml and M2: When we set (M1, M2) = (0, 0) and (2, 0), injury is not resolved as the states result in tissue steady state 3 (Table 7) where DAMPs is at MEDIUM (33%). For the other four possible values of Ml and M2, the states result in tissue steady state 1 from Table 7 where injury is resolved (DAMPs is LOW, 66%)
  3. ** Values not determined for M1 and M2: Assigning all possible combinations (100%) of the missing values result in the largest steady state (steady state 1) where injury is resolved
  4. *** indication of % injury resolved or unresolved resulting from assigning all possible values for undetermined nodes as explained in * and **