Fig. 3

Schematic representation of the mammalian circadian clock. Light stimulates the transcription of gene Per. The complex CLOCK-BMAL1 inhibits the transcription of gene Bmal1 and activates the transcription of genes Cry and Per. Notations: ∅: degradation product; the different forms of a given protein are noted cyto: cytosolic form, nuc: nuclear form; P: phosphorylated form