Skip to main content

Advertisement

Fig. 4 | BMC Systems Biology

Fig. 4

From: Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures

Fig. 4

Applicability of the rTK models trained in adult zebrafish to other life-stages of zebrafish and to other fish species. a The predicted log10 BCF vs. the observed log10 BCF values of 55 chemicals measured in zebrafish embryos using the optimized source and sink 7C model (RMSE = 1.220). b The predicted log10 BCF vs. the observed log10 BCF values measured in zebrafish embryos using the 1C model (RMSE = 0.812). c The predicted log10 BCF values vs. the observed log10 BCF values of 97 chemicals measured in 31 species of fish (653 total measurements) using the optimized source and sink 7C model. d The predicted log10 BCF values vs. the observed log10 BCF values from different species using the 1C model. e Histogram depicting the number of species with RMSE values for the predicted vs. observed BCFs within a range of values (bin size = 0.2) for the optimized source and sink 7C model. f Histogram depicting the number of species with RMSE values for the predicted vs. observed BCFs within a range of values (bin size = 0.2) for the 1C model. The 7C model demonstrates an improvement in the predictability of the BCF values over the 1C model (p = 0.0078, Student’s t-test), however, both models demonstrate 95% confidence intervals for RMSE above zero (0.687–1.0 for 7C, 0.99–1.32 for 1C)

Back to article page