Fig. 5From: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in miceThe temporal simulations of the PK modules were consistent with diverse experimental data. The temporal simulations of the plasma concentrations of anidulafungin (a), caspofungin (b), micafungin (c) and smx (d) were compared to relevant experimental data. The black dots and black solid curves represent the construction data and corresponding model simulations; the colored dots and colored dashed curves represent the validation data and corresponding simulations. The data sources were elaborated in Table 2. The colors in each panel were used to indicate different administration methods and dosages. In a, blue, i.v. of 1Â mg/kg; magenta, green and red, i.p. of 80Â mg/kg, 20Â mg/kg and 5Â mg/kg respectively. In b, blue and magenta, i.v. of 0.5Â mg/kg and 5Â mg; red, cyan and green, i.p. of 1Â mg/kg, 5Â mg/kg and 80Â mg/kg; In c, blue, red and green, i.v. of 0.32Â mg/kg, 1Â mg/kg and 3.2Â mg/kg; cyan and magenta, i.p. of 5Â mg/kg and 80Â mg/kg; In d, blue, oral of 50Â mg/kgBack to article page