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Table 3 Estimated Initial AC concentrations of echinocandins and SMX for model prediction

From: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice

Applied dosage (mg/kg) Initial Anidulafungin concentration (μg/ml) Initial Caspofungin concentration (μg/ml) Initial Micafungin concentration (μg/ml)
10 90 based on Data in [35] 12 25
5 30 based on Data in [42] 10 based on Data in [40] 15 based on the Data in [40]
2.5 15 8 10
1 10 2.5 5
0.5 5 1.5 3
0.1 1 0.8 1
  1. * For SMX, 500 and 550 (μg/ml) were used for applied dosages of 200 and 250 (mg/kg) respectively