A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice

BMC Systems Biology

Table 3 Estimated Initial AC concentrations of echinocandins and SMX for model prediction

Applied dosage (mg/kg)	Initial Anidulafungin concentration (μg/ml)	Initial Caspofungin concentration (μg/ml)	Initial Micafungin concentration (μg/ml)
10	90 based on Data in [35]	12	25
5	30 based on Data in [42]	10 based on Data in [40]	15 based on the Data in [40]
2.5	15	8	10
1	10	2.5	5
0.5	5	1.5	3
0.1	1	0.8	1

* For SMX, 500 and 550 (μg/ml) were used for applied dosages of 200 and 250 (mg/kg) respectively

ISSN: 1752-0509