Fig. 7

Tumor suppressor genes show increased expression in PcTF-expressing cancer cell lines. a Individual log10(FPKM) (color scale) for each of the tumor suppressor genes in (a). Black boxes highlight BRCA pathway genes. Genes are sorted from lowest to highest expression in untreated MCF7 cells. Numbers in the PcTF-treatment columns show log2 fold change values compared to UT. 15, infinite positive fold change where no expression was detected in untreated cells; − 15, infinite negative fold-change where no expression was detected in treated cells. b The diagram illustrates known pathways and interactions involving the genes shown in (b), based on information from the following Pathway Commons (http://www.pathwaycommons.org/) search results: ISG15 antiviral mechanism (Reactome), Interferon alpha/beta signaling (Reactome), SUMOylation of DNA damage response and repair proteins (Reactome), PPARA activates gene expression (Reactome), Fibronectin matrix formation (Reactome). c Box plots show expression values (center line, median; lower and upper boxes, 25th and 75th percentiles; lower and upper whiskers, minimum and maximum) across three time points (24, 48, and 72 h) for fifteen tumor suppressor genes where upregulation was at last two-fold (q ≤ 0.05) relative to the untreated control (UT) in at least one of the cell lines