Fig. 4

Model fits on experimental data using DOPS. The model parameters were estimated using DOPS. Solid black lines indicate the simulated mean thrombin concentration using parameter vectors from 25 trials. The grey shaded region represents the 99% confidence estimate of the mean simulated thrombin concentration. The experimental data is reproduced from the synthetic plasma assays of Mann and co-workers. Thrombin generation is initiated by adding Factor TF/VIIa (5nM (blue) and 5pM (red)) to synthetic plasma containing 200 μmol/L of phospholipid vesicles (PCPS) and a mixture of coagulation factors (II,V,VII,VIII,IX,X and XI) at their mean plasma concentrations