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Table 3 Nodes of the overall regulatory module with highest betweenness centrality

From: Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin

CADRE-IDs AspGD-IDs Protein names Degree BC log2FC
T 0.5 h T 1 h T 4 h T 8 h P 4 h P 8 h S 8 h
CADAFUBP00007914 AFUB_081260 Peptidyl-arginine deiminase domain protein 4 0.6 0.696 3.125 2.328 1.647 NA NA NA
CADAFUBP00001626 AFUB_016580 Long-chain-fatty-acid-CoA ligase, putative 11 0.405 −1.395 −1.605 −0.406 −0.750 NA NA NA
CADAFUBP00006564 AFUB_067450 Polyubiquitin UbiD/Ubi4, putative 111 0.396 −0.762 0.238 −0.248 −0.688 NA NA NA
CADAFUBP00008739 AFUB_089890 Mandelate racemase/muconate lactonizing enzyme family protein 10 0.304 1.791 0.546 0.247 0.055 NA NA NA
CADAFUBP00003378 AFUB_034540 Lysophospholipase 3 5 0.303 0.906 1.357 1.185 1.357 0.706 0.937 1.513
CADAFUBP00002707 AFUB_027690 Lysophospholipase 10 0.273 −1.454 −0.217 −0.854 −1.700 0.387 0.192 NA
CADAFUBP00006379 AFUB_065540 Patatin-like phospholipase domain-containing protein 10 0.273 −0.639 − 0.570 −0.931 −1.460 NA NA NA
CADAFUBP00008747 AFUB_089980 Ribosome biogenesis protein (Rrs1), putative 26 0.259 1.045 −0.096 −0.154 0.413 0.185 0.045 NA
CADAFUBP00004062 AFUB_041460 Plasma membrane ATPase 4 0.25 −1.535 −0.670 −1.002 −1.152 0.041 −0.023 1.910
CADAFUBP00005096 AFUB_052070 Plasma membrane ATPase 4 0.25 −0.378 − 0.299 0.441 0.463 NA NA NA
CADAFUBP00000491 AFUB_004970 Alcohol dehydrogenase, zinc-containing, putative 3 0.167 −1.712 −1.178 −1.125 −0.941 −0.759 −0.454 0.914
  1. Top ten nodes of the overall regulatory module showing the highest betweenness centrality (BC) and additional information regarding their node degree and gene- or protein-associated log2 Fold Change (log2FC) measured for the transcriptomic (T), proteomic (P) and secretomic (S) fungal response to caspofungin at all time points, respectively