Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin

Table 3 Nodes of the overall regulatory module with highest betweenness centrality

CADRE-IDs	AspGD-IDs	Protein names	Degree	BC	log2FC
CADRE-IDs	AspGD-IDs	Protein names	Degree	BC	T 0.5 h	T 1 h	T 4 h	T 8 h	P 4 h	P 8 h	S 8 h
CADAFUBP00007914	AFUB_081260	Peptidyl-arginine deiminase domain protein	4	0.6	0.696	3.125	2.328	1.647	NA	NA	NA
CADAFUBP00001626	AFUB_016580	Long-chain-fatty-acid-CoA ligase, putative	11	0.405	−1.395	−1.605	−0.406	−0.750	NA	NA	NA
CADAFUBP00006564	AFUB_067450	Polyubiquitin UbiD/Ubi4, putative	111	0.396	−0.762	0.238	−0.248	−0.688	NA	NA	NA
CADAFUBP00008739	AFUB_089890	Mandelate racemase/muconate lactonizing enzyme family protein	10	0.304	1.791	0.546	0.247	0.055	NA	NA	NA
CADAFUBP00003378	AFUB_034540	Lysophospholipase 3	5	0.303	0.906	1.357	1.185	1.357	0.706	0.937	1.513
CADAFUBP00002707	AFUB_027690	Lysophospholipase	10	0.273	−1.454	−0.217	−0.854	−1.700	0.387	0.192	NA
CADAFUBP00006379	AFUB_065540	Patatin-like phospholipase domain-containing protein	10	0.273	−0.639	− 0.570	−0.931	−1.460	NA	NA	NA
CADAFUBP00008747	AFUB_089980	Ribosome biogenesis protein (Rrs1), putative	26	0.259	1.045	−0.096	−0.154	0.413	0.185	0.045	NA
CADAFUBP00004062	AFUB_041460	Plasma membrane ATPase	4	0.25	−1.535	−0.670	−1.002	−1.152	0.041	−0.023	1.910
CADAFUBP00005096	AFUB_052070	Plasma membrane ATPase	4	0.25	−0.378	− 0.299	0.441	0.463	NA	NA	NA
CADAFUBP00000491	AFUB_004970	Alcohol dehydrogenase, zinc-containing, putative	3	0.167	−1.712	−1.178	−1.125	−0.941	−0.759	−0.454	0.914

Top ten nodes of the overall regulatory module showing the highest betweenness centrality (BC) and additional information regarding their node degree and gene- or protein-associated log2 Fold Change (log2FC) measured for the transcriptomic (T), proteomic (P) and secretomic (S) fungal response to caspofungin at all time points, respectively

ISSN: 1752-0509