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Table 2 Experimental vs Response surface predictions and statistical values calculated from fermentations used for model validation

From: Metabolic modeling and response surface analysis of an Escherichia coli strain engineered for shikimic acid production

initial GLC:YE g/L   75:20   80:40   115:45   %Error
   Exp. Model Exp. Model Exp. Model Average
Max biomass [g/L] 9.30 8.40 14.30 16.03 19.76 18.05 7.18
Consumed GLC [g/L] 70.03 70.70 80.11 78.19 115.76 113.84 1.18
Final SA [g/L] 24.62 22.13 33.19 26.62 31.84 32.96 7.88
Final AC [g/L] 5.25 6.45 0.00 0.85 4.90 8.73 35.70
μ max [h −1] 0.62 0.73 0.78 0.77 0.55 0.65 8.56
\(q_{glc}^{exp}\) [g/Lh] 0.89 1.17 0.93 0.97 0.73 0.99 17.03
\(q_{sa}^{exp}\) [g/Lh] 0.36 0.42 0.32 0.28 0.24 0.24 7.35
\(q_{glc}^{sta}\) [g/Lh] 0.33 0.32 0.38 0.39 0.41 0.42 2.07
\(q_{sa}^{sta}\) [g/Lh] 0.15 0.13 0.18 0.18 0.15 0.15 2.88
Y ps [g/g] 0.41 0.36 0.35 0.29 0.34 0.23 14.49
Y px [g/g] 0.59 0.59 0.42 0.38 0.44 0.38 5.68