Fig. 5

While cholesterol is evenly distributed in all brain regions studied, it is converted to 24S-cholesterol mostly in the cortical regions and hippocampus. Two plant-based cholesterol derivatives, campesterol and desmosterol, are also detected. Bar graphs are mean ± SD metabolite concentration. Asterisks (*) indicates statistical significance between the regions estimated by Welch’s two-sample t-test. (*: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001, ****: p ≤ 0.0001). OB, olfactory bulb; FCX, frontal cortex; HC, hippocampus; CBL, cerebellum