Table 3 Gene Ontology terms associated with top 100 hub genes of the enzalutamide resistance-modulated differential network
From: scdNet: a computational tool for single-cell differential network analysis
Category | Term | Gene count | P-value |
|---|---|---|---|
Annotation Cluster 1 (Enrichment Score: 3.43) | |||
CC | GO:0044429~mitochondrial part | 15 | 5.6 × 10−6 |
CC | GO:0005739~mitochondrion | 19 | 2.9 × 10−5 |
CC | GO:0031980~mitochondrial lumen | 8 | 3.1 × 10−4 |
Annotation Cluster 2 (Enrichment Score: 3.17) | |||
CC | GO:0044429~mitochondrial part | 15 | 5.6 × 10−6 |
CC | GO:0005740~mitochondrial envelope | 12 | 2.4 × 10−5 |
CC | GO:0005739~mitochondrion | 19 | 2.9 × 10−5 |
Annotation Cluster 3 (Enrichment Score: 2.38) | |||
CC | GO:0031974~membrane-enclosed lumen | 26 | 1.9 × 10−5 |
CC | GO:0070013~intracellular organelle lumen | 24 | 9.0 × 10−5 |
CC | GO:0043233~organelle lumen | 24 | 1.3 × 10−4 |
Annotation Cluster 4 (Enrichment Score: 1.90) | |||
MF | GO:0003743~translation initiation factor activity | 5 | 4.6 × 10−4 |
MF | GO:0008135~translation factor activity, nucleic acid binding | 5 | 2.7 × 10−3 |
BP | GO:0006412~translation | 8 | 3.2 × 10−3 |
Annotation Cluster 5 (Enrichment Score: 1.74) | |||
BP | GO:0016071~mRNA metabolic process | 8 | 5.8 × 10−3 |
BP | GO:0006397~mRNA processing | 7 | 1.1 × 10−2 |
BP | GO:0000375~RNA splicing, via transesterification reactions | 5 | 1.2 × 10− 2 |