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Fig. 2 | BMC Systems Biology

Fig. 2

From: Constructing network topologies for multiple signal-encoding functions

Fig. 2

Modular pools for oscillation and adaptation. a Distribution of networks capable of achieving function F1 in the space of the Q1-value and the number of edges. A total of 81 three-node networks (73 plus 8) are selected into the F1 modular pool, as highlighted in the dashed boxes. b Clustering of 73 networks as marked in (a). Each row in the clustering figure demonstrates the regulations among the three nodes within a network. Positive, negative and null regulations within the networks are denoted by red, green and black, respectively. The core oscillation motifs are labeled a1, a2, a3 and a4 as shown. c Eight simple F1 circuits, as marked in (a), that contain explicitly no oscillation motifs. d ~f Similar analyses of 81 three-node networks (76 plus 5) that construct the F2 modular pool. (f) The 5 simplest topologies as marked in (d) all of which contain implicit interactions due to the competitive effects. (g, h) Examples of functional networks with implicit motifs for functions F1 and F2, respectively, with competitive edges highlighted in blue. The dashed linkages denote the implicit interactions due to competition effects. The implicit regulations plus explicit linkages in the network form the ordinary F1 and F2 motifs (highlighted in grey)

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