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Fig. 5 | BMC Systems Biology

Fig. 5

From: Constructing network topologies for multiple signal-encoding functions

Fig. 5

Dynamics analysis for the tri-functional network N5 in Fig.4c. a Oscillations result from I1 signal stimulation of two different strengths. b Transient activation or adaptation triggered by signal I2 of low and high strength. c Sustained activation when signal I3 of different amplitudes acts upon node R3. d Bifurcation diagram for function F1 when the amplitude of signal I1 is tuned. (e) and (f) show the steady state concentrations as functions of I2 and I3 signal strength, respectively. The low and high signal strengths in (a-c) correspond to 0.5 and 1.0, respectively. I1 = I2 = I3 = 0.1 are adopted when no signal is present. The unit of time is arbitrary. Other parameters used in simulations: V1 = 0.3156, V2 = 1.8362, V3 = 0.7503, V4 = 0.5559, V5 = 2.3514, V6 = 0.2716, V7 = 0.7010, V8 = 0.6726, K1 = 5.1160, K2 = 0.3030, K3 = 0.0111, K4 = 1.2833, K5 = 0.0259, K6 = 0.0277, K7 = 0.0014, K8 = 0.0099, B = 0.5

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