Model-based virtual patient analysis of human liver regeneration predicts critical perioperative factors controlling the dynamic mode of response to resection

Table 1 Optimal values of the parameters corresponding to patient ID71 from Yamamoto et al. [18]

Parameter	Optimized value	Parameter	Optimized value
M	5.8206	k_deg	6.9843
k_IL6	1.4528	κ_ECM	32.9924
κ_IL6	0.6878	k_GF	0.1014
V_JAK	20,000	κ_GF	0.2016
\( {\mathrm{K}}_{\mathrm{M}}^{\mathrm{JAK}} \)	9999.9999	k_up	0.0589
κ_JAK	0.1695	k_QP	0.0072
[proSTAT3]	1.9108	k_PR	0.0045
V_ST3	749.9994	k_RQ	0.0520
\( {\mathrm{K}}_{\mathrm{M}}^{\mathrm{ST}3} \)	0.1715	k_prol	0.0232
κ_ST3	0.0828	k_req	0.0912
V_SOCS3	24,000.0000	θ_req	7.9493
\( {\mathrm{K}}_{\mathrm{M}}^{\mathrm{SOCS}3} \)	0.0006	β_req	2.9285
κ_SOCS3	0.3173	k_ap	0.0982
\( {\mathrm{K}}_{\mathrm{I}}^{\mathrm{SOCS}3} \)	0.0153	θ_ap	0.0321
V_IE	249.9992	β_ap	0.0045
\( {\mathrm{K}}_{\mathrm{M}}^{\mathrm{IE}} \)	17.9736	k_G	0.0007
κ_IE	4.9595