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Table 1 Growth rates, iron concentrations, and import rates in ΔΔ and WT cells grown under different nutrient conditions. [N] refers to the μM concentration of iron in the respiring medium, as described [34]. The untreated medium was assumed to contain 1 μM of endogenous iron. For each entry, the top number is datum or data-based estimates (R…-dat) and the bottom number is the corresponding simulated value (R…-sim). Concentrations are in units of μM, rates are in units of μM/hr., and αcell is in units of hr.− 1. Data for αcell and [Fecell] have been published [34] whereas [Fecyt], [Femit], and [Fevac] were estimated as described in the text

From: A mathematical model of iron import and trafficking in wild-type and Mrs3/4ΔΔ yeast cells

[N] αcell [Fecell] R cell fcyt[Fecyt] fmit [Femit] fvac [Fevac] R cyt - R mit - R vac R mit R vac
WT
 1 0.18 120 22 79 41 0 18 9.2 0
0.18 60 10 22 22 16 5.0 4.9 3.7
 2 0.18 200 37 75 43 82 17 9.9 19
0.19 190 35 76 35 81 18 8.4 19
 11 0.20 480 97 200 56 220 52 14 56
0.20 810 160 180 66 560 45 17 140
 41 0.20 880 180 310 69 500 77 18 130
0.20 900 180 180 69 640 46 18 160
ΔΔ
 1 0.06 360 22 110 69 180 8.1 5.2 14
0.05 540 27 240 74 230 13 3.9 12
 2 0.068 680 46 130 69 480 11 5.9 41
0.069 1100 90 380 77 660 33 6.6 58
 11 0.15 2200 320 280 72 1800 52 13 340
0.15 2300 360 280 71 1900 53 13 360
 41 0.20 3900 800 230 74 3600 59 19 920
0.19 2000 390 230 61 1800 54 14 410