Table 2 Optimized parameters used in simulations
From: A mathematical model of iron import and trafficking in wild-type and Mrs3/4ΔΔ yeast cells
Parameter | Value (strain) | units | Sensitivity |
|---|---|---|---|
f cyt | 0.8 | none | 1.051 |
f mit | 0.1 | none | 1.042 |
f vac | 0.1 | none | 1.001 |
C1 | |||
Rcell-max | 180 (WT) | μM hr.−1 | 1.021 |
390 (ΔΔ) | 1.049 | ||
KN | 4 | μM | 1.062 |
sens | 2 | none | 1.043 |
αmax | 0.204 | hr−1 | 1.068 |
Kα | 0.13(WT) | hr−1 | 1.047 |
3.9 (ΔΔ) | 1.029 | ||
C3 | |||
Rcyt | 230 (WT) | μM hr.−1 | 1.011 |
480 (ΔΔ) | 1.024 | ||
kmit(C3) | 2.8(WT) | hr−1 | 1.001 |
1.6 (ΔΔ) | 1.000 | ||
Rvac-max | 1140 | μM hr.−1 | 1.000 |
Kvac | 11 | μM | 1.001 |
nvac | 3 | none | 1.001 |
C4 | |||
Rcia-max | 56 | μM hr.−1 | 1.001 |
Kcia | 3.8 | μM | 1.000 |
ncia | 3 | none | 1.000 |
C9 | |||
kmit | 5.5(WT) | hr−1 | 1.000 |
1.2 (ΔΔ) | 1.000 | ||
Risu-max | 180 | μM hr.−1 | 1.005 |
Kisu | 220 | μM | 1.021 |
nisu | 2.3 | none | 1.106 |
kvp | 1.10 × 10−7 (WT) | μM1-nvp hr.−1 | 1.000 |
2.37 × 10− 7 (ΔΔ) | 1.000 | ||
nvp | 2.4 | none | 1.001 |
k23 | 5.2 | hr−1 | 1.000 |
[FS]sp | 370 | μM | 1.000 |
n23 | 1.6 | none | 1.000 |
kmp | 0.09 | μM−1 h−1 | 1.013 |
kO2 | 25 | hr−1 | 1.008 |
kres | 9 | μM−1 h− 1 | 1.010 |