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Table 2 Optimized parameters used in simulations

From: A mathematical model of iron import and trafficking in wild-type and Mrs3/4ΔΔ yeast cells

Parameter Value (strain) units Sensitivity
f cyt 0.8 none 1.051
f mit 0.1 none 1.042
f vac 0.1 none 1.001
C1
Rcell-max 180 (WT) μM hr.−1 1.021
390 (ΔΔ) 1.049
KN 4 μM 1.062
sens 2 none 1.043
 αmax 0.204 hr−1 1.068
Kα 0.13(WT) hr−1 1.047
3.9 (ΔΔ) 1.029
C3
Rcyt 230 (WT) μM hr.−1 1.011
480 (ΔΔ) 1.024
kmit(C3) 2.8(WT) hr−1 1.001
1.6 (ΔΔ) 1.000
Rvac-max 1140 μM hr.−1 1.000
Kvac 11 μM 1.001
nvac 3 none 1.001
C4
Rcia-max 56 μM hr.−1 1.001
Kcia 3.8 μM 1.000
ncia 3 none 1.000
C9
kmit 5.5(WT) hr−1 1.000
1.2 (ΔΔ) 1.000
Risu-max 180 μM hr.−1 1.005
Kisu 220 μM 1.021
nisu 2.3 none 1.106
kvp 1.10 × 10−7 (WT) μM1-nvp hr.−1 1.000
2.37 × 10− 7 (ΔΔ) 1.000
nvp 2.4 none 1.001
k23 5.2 hr−1 1.000
 [FS]sp 370 μM 1.000
n23 1.6 none 1.000
kmp 0.09 μM−1 h−1 1.013
kO2 25 hr−1 1.008
kres 9 μM−1 h− 1 1.010