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Volume 5 Supplement 1

Selected articles from the 4th International Conference on Computational Systems Biology (ISB 2010)


Edited by Luonan Chen, Xiang-Sun Zhang and Yong Wang

The 4th International Conference on Computational Systems Biology (ISB 2010). Go to conference site.

Suzhou, P. R. China9-11 September 2010

  1. Content type: Report

    Bi-directional gene pairs have received considerable attention for their prevalence in vertebrate genomes. However, their biological relevance and exact regulatory mechanism remain less understood. To study th...

    Authors: Bingchuan Liu, Jiajia Chen and Bairong Shen

    Citation: BMC Systems Biology 2011 5(Suppl 1):S2

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  2. Content type: Report

    Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role in response to hypoxic stress in living organisms. The HIF pathway is activated by changes in cellular oxygen levels and has ...

    Authors: Chia-Sheng Chuang, Tun-Wen Pai, Chin-Hua Hu, Wen-Shyong Tzou, Margaret Dah-Tsyr Chang, Hao-Teng Chang and Chih-Chia Chen

    Citation: BMC Systems Biology 2011 5(Suppl 1):S3

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  3. Content type: Report

    Identification of gene regulatory networks is useful in understanding gene regulation in any organism. Some regulatory network information has already been determined experimentally for model organisms, but mu...

    Authors: Rachita Sharma, Patricia A Evans and Virendrakumar C Bhavsar

    Citation: BMC Systems Biology 2011 5(Suppl 1):S4

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  4. Content type: Report

    A protein binding hot spot is a cluster of residues in the interface that are energetically important for the binding of the protein with its interaction partner. Identifying protein binding hot spots can give...

    Authors: Zhenhua Li, Limsoon Wong and Jinyan Li

    Citation: BMC Systems Biology 2011 5(Suppl 1):S5

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  5. Content type: Report

    Enzymes are known as the largest class of proteins and their functions are usually annotated by the Enzyme Commission (EC), which uses a hierarchy structure, i.e., four numbers separated by periods, to classif...

    Authors: Yong-Cui Wang, Yong Wang, Zhi-Xia Yang and Nai-Yang Deng

    Citation: BMC Systems Biology 2011 5(Suppl 1):S6

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  6. Content type: Report

    For understanding cellular systems and biological networks, it is important to analyze functions and interactions of proteins and domains. Many methods for predicting protein-protein interactions have been dev...

    Authors: Morihiro Hayashida, Mayumi Kamada, Jiangning Song and Tatsuya Akutsu

    Citation: BMC Systems Biology 2011 5(Suppl 1):S8

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  7. Content type: Report

    Comprehensive kinetic models of microbial metabolism can enhance the understanding of system dynamics and regulatory mechanisms, which is helpful in optimizing microbial production of industrial chemicals. Clostr...

    Authors: Ru-Dong Li, Yuan-Yuan Li, Ling-Yi Lu, Cong Ren, Yi-Xue Li and Lei Liu

    Citation: BMC Systems Biology 2011 5(Suppl 1):S12

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  8. Content type: Report

    In this paper the dynamics of the transcription-translation system for XlnR regulon in Aspergillus niger is modeled. The model is based on Hill regulation functions and uses ordinary differential equations. The n...

    Authors: Jimmy Omony, Leo H de Graaff, Gerrit van Straten and Anton J B van Boxtel

    Citation: BMC Systems Biology 2011 5(Suppl 1):S14

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  9. Content type: Report

    Revealing the multi-equilibrium property of a metabolic network is a fundamental and important topic in systems biology. Due to the complexity of the metabolic network, it is generally a difficult task to stud...

    Authors: Hong-Bo Lei, Ji-Feng Zhang and Luonan Chen

    Citation: BMC Systems Biology 2011 5(Suppl 1):S15

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  10. Content type: Report

    Type 2 diabetes mellitus (T2DM) is a complex systemic disease, with significant disorders of metabolism. The liver, a central energy metabolic organ, plays a critical role in the development of diabetes. Altho...

    Authors: Huarong Zhou, Shigeru Saito, Guanying Piao, Zhi-Ping Liu, Jiguang Wang, Katsuhisa Horimoto and Luonan Chen

    Citation: BMC Systems Biology 2011 5(Suppl 1):S16

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  11. Content type: Report

    Human iPS cells (hiPSCs) have attracted considerable attention for applications to drug screening and analyses of disease mechanisms, and even as next generation materials for regenerative medicine. Genetic re...

    Authors: Shigeru Saito, Yasuko Onuma, Yuzuru Ito, Hiroaki Tateno, Masashi Toyoda, Akutsu Hidenori, Koichiro Nishino, Emi Chikazawa, Yoshihiro Fukawatase, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Yohichi Shimma, Akihiro Umezawa, Jun Hirabayashi, Katsuhisa Horimoto…

    Citation: BMC Systems Biology 2011 5(Suppl 1):S17

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2017 Journal Metrics

  • Citation Impact
    2.05 - 2-year Impact Factor
    2.505 - 5-year Impact Factor
    0.689 - Source Normalized Impact per Paper (SNIP)
    1.109 - SCImago Journal Rank (SJR)


    Social Media Impact
    523 mentions