A simple principle concerning the robustness of protein complex activity to changes in gene expression

BMC Systems Biology

Table 1 Protein complexes with essential functions are not enriched for subunits with over-expression phenotypes.

	Percentage genes with over-expression phenotype (total number of genes)	P-value
All protein complex subunits	16% (943)
Complex with no essential subunits	18% (255)
Complex with at least one essential subunit	15% (688)	0.28^a
Complex with >= 25% essential subunits	16% (447)	0.56^a
Complex with >= 50% essential subunits	15% (371)	0.24^a
Essential subunits of protein complex	14% (342)	0.24^b

^a Significance of difference between the subunits of protein complexes with any, >= 25% or >= 50% essential subunits and the subunits of other complexes (Chi square test, 1 dof).
^b Significance of difference between essential and non-essential subunits of protein complexes (Chi square test, 1 dof).

ISSN: 1752-0509