Table 2 Parameter names, values, units and sources.
From: Essential operating principles for tumor spheroid growth
Parameter | In silico value | In vitro value | Source |
|---|---|---|---|
Proliferating NUTRIENT critical level (proNut) | 3.0 × 10-3 | 3.0 × 10-19 mol/μm3 | Tuned parameter |
Quiescent NUTRIENT critical level (quiNut) | 8.0 × 10-4 | 8.0 × 10-20 mol/μm3 | Tuned parameter |
Proliferating CELL'S NUTRIENT uptake (proConsumeRate) | 5.0 × 10-4/SEC | 5.0 × 10-17 mol/(cell s) | [17] |
Quiescent CELL'S NUTRIENT uptake (quiConsumeRate) | 1.0 × 10-4/SEC | 1.0 × 10-17 mol/(cell s) | Tuned parameter |
Delay before dead CELL is removed (removeDelay) | 3.6 × 104 SEC | 1.8 × 104 s | [35] |
Movement bias (moveEmptyBias) | 1.0 | -- | Tuned parameter |
Delay between CELL creation events (prolifDelay) | 800 SEC | 800 s | Tuned parameter |
Proliferation bias (proBias) | 2.25 | -- | Tuned parameter |
NUTRIENT diffusivity (diffusionRate) | 0.28* | 105 μm2/s | [17] |
Initial NUTRIENT concentration (initialVal) | 0.165 or 0.008 | 16.5 mM or 0.8 mM | [27] |
Time step | 1.0 SEC | 1.0 s | Calculated |
CELL diameter | 1 grid space | 10 μm | [26] |
Average cell cycle** | ~4.24 × 104 SEC | ~4.24 × 104 s | Calculated |
Average time of removal after cell death** | 1.8 × 104 SEC | 1.8 × 104 s | Calculated |