Essential operating principles for tumor spheroid growth

BMC Systems Biology

Table 5 Effects of increasing parameters on in silico measures.

Parameter	Maximum size	Viable rim width	Quiescence onset	Necrosis onset	Growth rate	Doubling time	Stability	Necrotic core size
DiffusionRate	↑	↑	↑	↑	--	--	↔	↔
initialVal	↑	↑	↑	↑	↓	↓	↔	↑
proConsumeRate	↓	↓	↓	↓	--	--	--	↔
quiConsumeRate	↓	↓	--	↔	--	--	--	↔
prolifDelay	↔	--	↑	↑	↓	↓	--	↔
removeDelay	↑	--	--	--	--	--	↔	↑
proNut	↔/--	--	↓	↓	--	--	↓	↔
quiNut	↓	↓	--	↓	↓	--	--	--/↓
proBias	↓	↑	↑	↑	↓	↓	--/↑	↓
moveEmptyBias	↔	↓/↑	--	--	↑	--	↑	↑

↑: Positive effect. ↓: Negative effect. ↔: Effect limited or not easily determined. --: No effect. Cells with two values (e.g. --/↑) indicate different effects at high nutrient (left) and low nutrient (right). Cells with one value indicate similar effect at high and low nutrient.
* Quiescence onset and necrosis onset are the measured times of onset. A positive effect indicates that the time of quiescence or necrosis onset increased, thus they occurred later in the simulation.

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