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Figure 1 | BMC Systems Biology

Figure 1

From: Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification

Figure 1

Developed hybrid optimization algorithm with tolerance adjustment consisting of the features: initialization within the feasible region (A); initial optimization using the SQP (B); interactive hybrid process using SQP (C); STRiN (D); and optimization control algorithm (E). f(Θ* k ): objective function value at the current local minimizer Θ* k ; χ2UL: upper limit of f(Θ* k ) to invoke STRiN (if f Θ* k ) <χ2UL; α: parameter scaling constant; Θ0: initial guess; Θ*: local minimizer from a successful sub-optimization; Θ°: iterate recorded for the smallest function value up to the current optimization trial; Θ ^ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaacceGaf8hMdeLbaKaaaaa@2D61@ : ultimate minimizer.

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