Figure 3
From: Exploiting the pathway structure of metabolism to reveal high-order epistasis
MCS target multiple E. coli subsystems. Minimal cut sets (MCS) for biomass production target 23 of 30 E. coli reaction subsystems. The most often targeted subsystems are "Cell Envelope Biosynthesis", "Threonine and Lysine Metabolism", "Alternate Carbon Metabolism", and "Extracellular Transport". 7 subsystems are not targeted by any MCS, including 'Alanine and aspartate metabolism', 'Anaplerotic reactions', 'Pyruvate metabolism', and 'Citrate Cycle (TCA)'. Subsystem annotations are taken from the original E. coli iJR904 model annotation [8]. For compactness, subsystems "Unassigned", "Putative", and "Putative Transporters" were not included in the subsystem signatures shown in the above figure.