Table 2 Yeast SL gene-pairs.

Single-strand and double-strand-3'-5' exonuclease activity for DNA repair and recombination.

Microtubule assembling

PAF1 complex. Interacts with RNA pol II. Causes hyperparathyroidism-jaw tu- mor syndrome

Interacts with helicase subunits of NER-transcription factor

Sister chromatid cohesion. Resistance to Campothecin anti-tumor agent

Histone chaperone

Initiation of DNA replication. Oncogenic activity through repression of INK4/ARF locus

Ubiquitin-conjugating enzymes without catalytic activity

Involved in cell cycle checkpoint enforcement. Colorectal cancer

Central roll in postreplicative DNA repair in eukaryotic cells

Removes 5' overhanging flaps in DNA repair and Okazaki fragments. Fast tumor progress

Component of anaphase promoting complex (APC), progression through mitosis and G1 phase

Core component of multiple cullin-RING-based SCF which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.

Component of the SCF.

form a complex required by DNA polymerase delta and epsilon.

DNA polymerase subunit.

form a complex recruited by DNA polymerase

DNA polymerase subunit