Skip to main content

Table 2 Yeast SL gene-pairs.

From: Human synthetic lethal inference as potential anti-cancer target gene detection

Yeast Human Biological process
YMR224C MRE11A Single-strand and double-strand-3'-5' exonuclease activity for DNA repair and recombination.
YER016W MAPRE1 Microtubule assembling
YLR418C CDC73 PAF1 complex. Interacts with RNA pol II. Causes hyperparathyroidism-jaw tu- mor syndrome
YIL128W MMS19 Interacts with helicase subunits of NER-transcription factor
YNL299W PAPD5 Sister chromatid cohesion. Resistance to Campothecin anti-tumor agent
YJL115W ASF1 Histone chaperone
YJL194W CDC6 Initiation of DNA replication. Oncogenic activity through repression of INK4/ARF locus
YGL087C UBE2V2 Ubiquitin-conjugating enzymes without catalytic activity
YJL013C BUB1 Involved in cell cycle checkpoint enforcement. Colorectal cancer
YGL058W UBE2B Central roll in postreplicative DNA repair in eukaryotic cells
YKL113C FEN1 Removes 5' overhanging flaps in DNA repair and Okazaki fragments. Fast tumor progress
YGL240W ANAPC10 Component of anaphase promoting complex (APC), progression through mitosis and G1 phase
*YDL132W CUL1 Core component of multiple cullin-RING-based SCF which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.
YOL133W RBX1 Component of the SCF.
*YBR087W RFC3 form a complex required by DNA polymerase delta and epsilon.
YNL102W POLA1 DNA polymerase subunit.
*YJR068W RFC4 form a complex recruited by DNA polymerase
YDL102W POLD1 DNA polymerase subunit
  1. Human homologs of the SL gene-pairs and the biological process that they fulfill. A preliminary candidates list, where a human gene is cancer-related (in bold) and its SL partner is not known to be directly related with cancer. Asterisk symbol indicates SL partners that belong to the same cellular pathway (within-pathway model: [23]) and are essential.