Figure 6

Persistence comparisons. (A) through (D) use the default VEGF gradient (Table 3). Visual examples of how directional persistence affects capillary sprout morphology. (A) and (B) show two snapshots of random tip cell movement (A) and 20% intrinsic persistence weighting (B) in tip cell movement, at 48 hours. (C) Total vessel length from 2–72 hrs for the model, comparing 20% to 40% intrinsic persistence. (D) Total vessel length change from 2–72 hrs comparing intrinsic persistence of 20% with global persistence at 20% and 40% directional weighting. For (C) and (D), VEGF concentration is set as a uniform 0.6 ng/ml at each voxel point in the grid, i.e., there is uniform concentration and no gradient. (E) Maximum XY-plane distance reached beyond initial capillary structures for intrinsic persistence weighting of 20% compared to a random weight. (F) Total vessel length from 2–72 hrs for 20% intrinsic persistence weighting vs. random movement.