|
Cluster
|
Num. of genes
|
Dominant transcription factors
|
Avg. of pair-wise correlations
|
P-value
|
|---|
|
A
|
18
|
NFKB1, RELA
|
0.5742
|
<0.001*
|
|
B
|
11
|
STAT1
|
0.7815
|
<0.001*
|
|
C
|
5
|
STAT3
|
0.5138
|
0.025
|
|
D
|
17
|
JUN, FOS
|
0.4054
|
0.001
|
|
E
|
6
|
MYC
|
0.4350
|
0.031
|
|
F
|
5
|
STAT6
|
0.7546
|
0.004
|
|
G
|
21
|
MYC
|
0.6442
|
<0.001*
|
- For N genes in a cluster, N(N-1)/2 pair-wise Pearson's correlations on expression were measured and their average was calculated. Next, N genes were randomly selected from a set of ~18,000 human genes and the average pair-wise correlation was calculated from the random gene set. The distribution of the average pair-wise correlation of random genes was re-estimated 1,000 times to generate a null distribution of the average pair-wise correlations. A p-value for each cluster was estimated by counting the number of random gene sets for which the average correlation is larger than the cluster correlation. *No random gene set that exceeded the cluster was found in 1,000 repeats.
