A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis

BMC Systems Biology

Table 2 Sensitivity coefficients for the parameters in modeling 3-NP inhibition.

Parameter p	Sensitivity Coefficient as a Function of [3-NP]
	0.001 mM	0.01 mM	0.1 mM	1 mM
w _ICL1	0.0000	0.0000	0.0000	0.0000
[SUC]	0.0004	0.4657	0.3380	0.0394
K _{3-NP, ICL1}	0.0000	0.0000	0.0000	0.0000
K _{3-NP, ICL2}	0.0000	0.0000	0.0000	0.0000
w _{MCL 1}	-0.0007	-1.4741	-3.8957	-0.8557
[C' ] (t = 0)	0.9609	1.2746	0.2596	0.0278
V _m	0.0060	1.3459	0.5908	0.0646
	-0.0032	-0.7049	-0.2555	-0.0277
K _{SUC, ICL1}	0.0000	0.0000	0.0000	0.0000
K _{SUC, ICL2}	0.0000	0.0000	0.0000	0.0000
K _{SUC, MCL 1}	-0.0004	-0.4657	-0.3377	-0.0393
K _{SUC, MCL 2}	-0.0000	-0.0000	-0.0003	-0.0001
K _{3-NP, MCL 1}	0.0007	0.7492	0.5432	0.0632
K _{3-NP, MCL 2}	0.0000	0.0002	0.0020	0.0008

The sensitivity coefficient was calculated from a numerical estimate of , where OD is the cell concentration expressed in units of optical density at 600-nm-wavelength light and p represents the analyzed parameter.

ISSN: 1752-0509