Reconstruction characteristics for i RS605. A. Statistics of the Francisella tularensis subspecies holarctica vaccine strain ( F. tularensis LVS) genome and its in silico reconstruction i RS605. The in silico representation includes gene-protein-reaction relationships including isozymes, multimeric protein complexes, and multi-reaction catalyzing enzymes as described in the text. B. Functional classification of genes that are included in the model. C. Overview of metabolism in Francisella. Significant interconnections between pathways are shown. Pathways with missing genes are indicated by cross symbols.