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Figure 4 | BMC Systems Biology

Figure 4

From: Ultrasensitive Responses and Specificity in Cell Signaling

Figure 4

Effect of increasing ultrasensitivity on mutual fidelity & mutual specificity. MFMS values for networks with CPI, CS, and SC were calculated for 10,000 trials over a large range of parameters (See below for parameter ranges). MFMS values at the 90th percentile of the distribution were then plotted as a function of degree of various Hill exponents. (A) Dependence of each type of network on n, the degree of ultrasensitivity in the X pathway, where ultrasensitivity in the Y pathway was set to one, m = 1. (B) Dependence on m, the ultrasensitivity of the Y pathway, where n = 1. (Parameter Ranges): C P I : { 1 a 1 / d 1 5 , 0.1 b 1 / d 1 1 , 0.1 a 2 / d 2 X 5 , 0.1 b 2 / d 2 Y 5 , .01 ε Y 10 } , C S : { 0.1 a 1 / d 1 1 , 1 b 1 / d 1 5 , 0.1 a 2 / d 2 X 5 , 0.1 b 2 / d 2 Y 5 , .01 ε Y 10 } , S c : { 1 a 1 / d 1 5 , 1 b 1 / d 1 5 , 0.1 a 2 / d 2 X 5 , 0.1 b 2 / d 2 Y 5 , .01 ε Y 10 } . .

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