Triangle motifs. The motifs were derived for each triple of nodes consisting of a hub and two of its neighbors in the network (n1, n2) which were also mutually connected. In the integration motif (motif A) all nodes are pair-wise highly co-regulated. Accordingly, the motif is defined by high correlations (low distances) for links hub-n1, hub-n2 and n1-n2. In contrast, the maintenance motif (motif B) consisted of a hub which was not co-regulated with its neighbors n1 and n2. Counted were triangles which pairs of hub-nodes (hub-n1 and hub-n2) showed high correlation in one tissue type and no correlation in the other, while the correlation of n1-n2 stayed in the same category. Motif C is a consistent feed-forward loop, taken from the literature .