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Table 3 Statistics of topology features and network motifs

From: Regulation patterns in signaling networks of cancer

 

Comparative network motif

Integration motif

Maintenance motif

Cluster coefficient

Cluster coefficient

> 0

Information entropy

 

normal

tumor

normal

tumor

normal

tumor

normal

tumor

normal

tumor

normal

tumor

AML 1

3.94E+07

1.08E+07

541

27

6

26

0.126

0.113

1924

2344

10.94

12.35

AML 2

3.35E+07

3.35E+06

888

0

0

139

0.142

0.119

1373

1971

10.05

12.22

Breast 1

1.82E+07

1.88E+07

34

55

10

6

0.116

0.115

2234

2244

12.07

12.11

Breast 2

2.62E+07

2.39E+07

272

169

17

15

0.119

0.119

2271

2338

11.98

12.05

Cervical 1

5.04E+07

1.19E+07

614

49

4

52

0.134

0.117

1924

2538

10.89

12.12

Cervical 2

2.57E+07

1.74E+07

170

58

2

17

0.118

0.116

2081

2278

11.71

12.16

ESCC

2.52E+07

1.52E+07

70

8

0

6

0.117

0.112

2236

2435

11.99

12.55

Glioma

3.02E+07

2.28E+07

250

92

3

43

0.118

0.115

2242

2450

11.91

12.20

Head and neck

1.31E+07

1.24E+07

205

143

3

14

0.129

0.123

1712

1700

11.38

11.39

Lung 1

1.42E+07

1.40E+07

83

78

15

18

0.124

0.123

1813

1832

11.82

11.57

Lung 2

2.31E+07

1.88E+07

154

99

8

17

0.117

0.117

2137

2233

11.81

12.05

Oral tongue 1

1.84E+07

9.83E+06

231

68

1

32

0.130

0.121

1768

1912

11.42

12.04

Oral tongue 2

3.06E+07

2.15E+07

144

34

3

30

0.121

0.115

2349

2489

11.76

12.23

Pancreas 1

4.20E+07

1.37E+07

1427

115

5

79

0.123

0.114

1873

2457

11.23

12.21

Pancreas 2

4.60E+07

1.16E+07

1250

81

0

81

0.126

0.112

1866

2504

11.19

12.33

Prostate 1

1.37E+07

8.91E+06

573

398

0

3

0.130

0.126

1407

1485

11.06

11.30

Prostate 2

3.07E+07

2.29E+07

178

56

13

24

0.116

0.117

2357

2541

11.79

12.15

Renal 1

2.25E+07

2.24E+07

105

123

20

29

0.119

0.119

2181

2190

11.70

11.69

Renal 2

5.72E+07

7.05E+06

1227

116

8

116

0.138

0.118

1650

2398

10.56

12.16

Vulva

2.81E+07

2.67E+07

231

308

33

23

0.123

0.123

2299

2295

11.57

11.58

Tendency for tumor

Down

Down

Up

Down

Up

Up

Significance (P-value)

9.54E-06

5.53E-04

6.34E-04

1.05E-04

1.91E-05

8.20E-05

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BMC Systems Biology

ISSN: 1752-0509

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