Table 1 Information on the ethanol and lycopene models, their corresponding EMs, and their reaction and pathway change in Gibbs free energy.

Number of reactions

60

64

Number of metabolites

47

50

Mean EMA Computation Time (s) (± SD)

8.04 s ± 0.27 s

12.30 s ± 0.24 s

Number of EMs

33,220

42,659

Number of product-producing EMs (%)

8,389 (25.3%)

9,439 (22.1%)

Number of biomass-producing EMs (%)

28,336 (85.3%)

32,763 (76.8%)

Number of product- and biomass-producing EMs (%)

7,156 (21.5%)

4,427 (10.4%)

Δ G _r ° Mean (kcal mol ¹ )

1.95

1.77

Δ G _r ° Skewness (kcal mol ¹ )

4.54

0.42

Δ G _p ° Mean (kcal mol ¹ )

111.87

88.72

Δ G _p ° Median (kcal mol ¹ )

71.71

50.40

Number of thermodynamically-infeasible EMs (%)

242 (0.73%)

1487 (3.49%)