Table 2 Significantly modulated metabolites from the polar fraction of the TCDD-exposed HepG2 (P < 0.01)a.
Metabolite | Log2 ratiob (1H NMR) | Log2 ratiob (LC-MS) |
|---|---|---|
Leucine, Isoleucine | -0.51 | -- |
Valine | -0.51 | -- |
Alanine | -0.51 | -- |
N-acetylaspartate | -0.51 | -0.51 |
Glutamate | -0.32 | -- |
Glutamine | -0.51 | -- |
Glycine | -0.51 | -- |
Aspartate | -0.51 | -- |
Serine | -0.51 | -- |
Tyrosine | -0.74 | -1.32 |
Proline | -- | -1.00 |
Tryptophan | -- | -0.32 |
Lactate | -1.00 | -- |
Spermidine | -- | -2.32 |
N1-acetyl-spermidine | -- | -0.74 |
Panthotenic acid | -- | -0.74 |
Creatine/Phosphocreatine | -0.51 | -- |
Propyonylcarnitine | -- | -0.51 |
Butyrylcarnitine | -- | -0.74 |
Nucleotides (AMP, ADP, ATP and UMP) | -1.74 to -0.74 | -- |
UMP | -- | -0.49 |
AMP | -- | -0.51 |
Oxidized glutathione | 0.38 | 0.38 |
Reduced glutathione | 0.68 | 0.26 |
Taurine | 0.49 | -- |
Citrate | 0.58 | 0.77 |