Table 3 Differentially regulated gene sets in Pkd1-/-animals
a) E14.5 | Â | Â |
|---|---|---|
Up-regulated | Â | NES |
HSA04630_JAK_STAT_SIGNALING_PATHWAY | JAK-STAT Pathway | 1.34 |
NGUYEN_KERATO_DN | Notch Signaling | 1.32 |
HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY | Adipocytokine Signaling | 1.3 |
HSA04210_APOPTOSIS | Apoptosis | 1.13 |
WNT_TARGETS | Wnt Signaling | 1.43 |
PARP_KO_UP | Genomic Integrity | 1.27 |
RACCYCDPATHWAY | Cell Cycle | 1.2 |
REN_E2F1_TARGETS | Cell Cycle | 1.19 |
Down-regulated | Â | Â |
LYSINE_DEGRADATION | Amino Acid Metabolism | -1.76 |
PROPANOATE_METABOLISM | Carbohydrate Metabolism | -1.64 |
CROONQUIST_IL6_RAS_DN | JAK-STAT Pathway | -1.44 |
YU_CMYC_UP | Myc regulated genes | -1.37 |
HSA00330_ARGININE_AND_PROLINE_METABOLISM | Amino Acid Metabolism | -1.27 |
HSA00620_PYRUVATE_METABOLISM | Carbohydrate Metabolism | -1.25 |
GLUCONEOGENESIS | Carbohydrate Metabolism | -1.21 |
GLYCOLYSIS | Carbohydrate Metabolism | -1.21 |
CELL_ADHESION_RECEPTOR_ACTIVITY | Cell Adhesion | -1.17 |
BETA_ALANINE_METABOLISM | Amino Acid Metabolism | -1.17 |
LEE_MYC_E2F1_DN | Myc regulated genes | -1.16 |
KERATINOCYTEPATHWAY | Mitogenic Pathway | -1.28 |
GLYCOGEN_METABOLISM | Carbohydrate Metabolism | -1.26 |
LI_FETAL_VS_WT_KIDNEY_UP | Wilm's Tumor Signature | -1.19 |
FATTY_ACID_METABOLISM | Lipid Metabolism | -1.11 |
b) E17.5 | Â | Â |
Up-regulated | Â | Â |
EGF_HDMEC_UP | Growth Factor Signaling | 1.76 |
G1_TO_S_CELL_CYCLE_REACTOME | Cell Cycle | 1.43 |
WNTPATHWAY | Wnt Signaling | 1.35 |
CROONQUIST_IL6_RAS_DN | JAK-STAT Pathway | 1.31 |
HSA04010_MAPK_SIGNALING_PATHWAY | MAPK Signaling | 1.23 |
ZMPSTE24_KO_UP | Ageing | 1.15 |
HSA04520_ADHERENS_JUNCTION | Cell Communication | 1.13 |
P38MAPKPATHWAY | MAPK Signaling | 1.02 |
WILLERT_WNT_NCCIT_ALL_UP | Wnt Signaling | 1.43 |
HIF1_TARGETS | Hypoxia Pathway | 1.4 |
Down-regulated | Â | Â |
TRYPTOPHAN_METABOLISM | Amino Acid Metabolism | -1.72 |
PROPANOATE_METABOLISM | Carbohydrate Metabolism | -1.38 |
HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS | Translation | -1.23 |
VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION | Amino Acid Metabolism | -1.14 |
HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM | Lipid Metabolism | -1.18 |
GLUCONEOGENESIS | Carbohydrate Metabolism | -1.11 |
GLYCOLYSIS | Carbohydrate Metabolism | -1.11 |