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Figure 1 | BMC Systems Biology

Figure 1

From: Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genes

Figure 1

Determining the posterior odds ratio (postOR). Gene network for five genes in the matrix metalloproteinases network determined separately in grade 1 breast cancer samples (a) and grade 3 samples (b). The posterior probabilities of gene-gene connection (in red) determined by GGM, support true edges in both tumor grades between MMP1 and MMP12, and between MMP12 and MMP9 (postProb ~ 1); and a true edge between MMP12 and MMP10 in grade 3 but not grade 1. The log posterior odds ratios of the probabilities (in red in panel c) quantify the magnitude of difference in connectivity across disease states. Data derived from GEO series 2990 [28]. See the results section for detail of the breast cancer data analysis.

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BMC Systems Biology

ISSN: 1752-0509

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