Figure 6

Differential gene connectivity as a function of overall connectivity for two breast cancer datasets. The differential gene connectivity for each gene is the number of genes with which the absolute log posterior oddsratio is greater than 55 for GSE2990 and 35 for GSE6532 (thresholds based on ~0.1% percentiles of the null distribution from 100 permutations). The overall connectivity is the number of genes with which the posterior probability of connection is over 90%, which represents about 3.5% of all the edges overall. The solid lines represent the quadratic fitted function and the dashed and dotted lines represent the 95% confidence and prediction intervals, respectively. The 10 genes with 30 or more differential connections in both datasets are labeled. Note that CXCL13 and MMP12 fall outside the 95% confidence and prediction intervals in both datasets.