Global scale Bayesian network from FMB applied to wild-type and lpdA gene knockout mutant of E. coli . Global scale Bayesian network was inferred from metabolic flux data on wild-type and lpdA mutant of E. coli. Number in each node indicates the cluster number (see Additional file 1 for details). Cluster 44 in red contains a reaction directly perturbed by genetic perturbation, and influences the largest number of nearby reactions. Cluster 1 in blue influences the second largest number of reactions.