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Figure 6 | BMC Systems Biology

Figure 6

From: Genome-scale modeling using flux ratio constraints to enable metabolic engineering of clostridial metabolism in silico

Figure 6

FBrAtio predictions of solvent production using the i CAC490 model and fixed ratios. The model was simulated given (i) a glucose uptake rate of 10 m m o l h r · g D C W , (ii) varied SPF, (iii) constraints listed in Table 1, (iv) unidirectional acetate and butyrate secretion by diffusion, (v) f (rTHL): f (rPTA) = 2, (vi) f (rTHL): f (rAAD_ 1) = 10, (vii) f (CO 2 export): f (CO 2 conversion) = 5, (viii) f (rPFO): f (rLDH) = 10, (ix) f (rCoAT, butrate): f (rCoAT, acetate) = 0.63, and (x) constant f (rCoAT): f (rBHBD) flux ratios of 1, 0.5, 0.1, and 0.01. The following curves are shown: acetone (cyan), butanol (red), and ethanol (green).

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