Table 4 Top 10 co-targets for countering drug resistance under INH treatment

radA

0.30

Not Essential

DNA repair protein

[55]

fadE10

0.19

Not Essential

acyl-CoA dehydrogenase

[56, 57]

Rv2165c

1.05

In Vitro essential

conserved hypothetical protein

[55]

echA17

0.25

Not Essential

enoyl-CoA hydratase

Rv2137c

1.32

Not Essential

conserved hypothetical protein

Ffh

0.25

In Vitro essential

signal recognition particle protein

[61–63]

fadE14

0.12

Not Essential

acyl-CoA dehydrogenase

[58]

fadA

0.20

Not Essential

acyl-CoA thiolase

[55]

fadE12

0.15

Not Essential

acyl-CoA dehydrogenase

[56, 57]

cysG

0.16

In Vitro essential

multifunctional siroheme synthase

[64]